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Dec 18, 2024 · Propofol-related Infusion Syndrome (PRIS) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of: metabolic acidosis; rhabdomyolysis; hyperlipidaemia; enlarged or fatty liver; MECHANISM. Poorly understood — even the central role of propofol has been questioned

PRIS was defined as metabolic acidosis plus cardiac dysfunction and at least one other variable including the fact that hypertriglyceridemia, rhabdomyolysis, and acute kidney injury occurred after the start of propofol. PRIS was found among 1.1% of patients (11 patients out of 1,017).

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Propofol-related infusion syndrome (PRIS) is a lethal condition characterized by multiple organ system failures. It can occur due to prolonged administration of propofol (an anesthetic) in mechanically intubated patients.

Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol. It can lead to cardiac failure, rhabdomyolysis, metabolic acidosis, and kidney failure, and is often fatal.

Propofol-related infusion syndrome (PRIS) is a rare yet often fatal syndrome that has been observed in critically ill patients receiving propofol for sedation. PRIS is charac-terized by severe unexplained metabolic acidosis, arrhythmias, acute renal failure, rhabdomyolysis, hyperkalemia, and cardiovascular collapse. Although the exact patho-

The clinical features of propofol infusion syndrome (PRIS) are acute refractory bradycardia leading to asystole, in the presence of one or more of the following: metabolic acidosis (base deficit > 10 mmol.l (-1)), rhabdomyolysis, hyperlipidaemia, and enlarged or fatty liver.

The propofol infusion syndrome (PRIS), a rare, often fatal, condition of unknown etiology, is defined by development of lipemic serum, metabolic acidosis, rhabdomyolysis, hepatomegaly, cardiac arrhythmias, and acute renal failure. ...

Mechanism PRIS: Propofol inhibits transport of fatty acids into the mitochondria and inhibits electron transport chain causing build up of fatty acid metabolites and decreased ATP; Made worse by a patient who is critically ill, has depleted carbohydrate stores, and thus relies on fatty acid breakdown for energy Clinical features: Metabolic acidosis

The term PRIS—propofol infusion syndrome—was originally coined by Bray in 1998 to describe the adverse effects associated with the use of propofol in the paediatric population.